Role of Ki67 in Predicting Response to Adjuvant Tamoxifen in Postmenopausal Hormonal Positive Breast Cancer Patients

Abstract

reast cancer is the most common cancer in women worldwide, with nearly 1.7 million new cases diagnosed in 2012 (second most common cancer overall). This represents about 12% of all new cancer cases and 25% of all cancers in women. It is the fifth most common cause of death from cancer in women. Most breast cancer subtypes are hormone-related. The natural history of the disease differs between those diagnosed before and after the menopause, which may be due to different kinds of tumour and possibly different effects of nutritional factors on hormones depending on menopausal status A central component of the treatment of breast cancer is full knowledge of extent of the disease and biologic features. These Factors contribute to the determination of the stage of the disease, assist in the estimation of the risk that the cancer will recur and provide information that predicts response to therapy.