Urinary Claudin-1 Level As a Marker of Podocyte Injury in Patients With Proteinuria
Eman Abdel-Mohsen Mousa Sanad;
Abstract
T
he biology of claudins is a rapidly evolving field, and many intriguing questions remain unanswered. Although it had been assumed that the reason there are ≥24 isoforms of claudin is that each one has distinct permeability properties. There is increasing evidence that many claudins are not only at the tight junction but found along the entire basolateral membrane.
Recent studies have clearly shown that the slit diaphragm is the structure likely to be the barrier of the glomerular capillary wall. Several molecules constituting the slit diaphragm were identified. Among them, nephrin, podocin, CD2AP, FAT and NEPH1 are accepted to be essential in maintaining the barrier function of the slit diaphragm.
he biology of claudins is a rapidly evolving field, and many intriguing questions remain unanswered. Although it had been assumed that the reason there are ≥24 isoforms of claudin is that each one has distinct permeability properties. There is increasing evidence that many claudins are not only at the tight junction but found along the entire basolateral membrane.
Recent studies have clearly shown that the slit diaphragm is the structure likely to be the barrier of the glomerular capillary wall. Several molecules constituting the slit diaphragm were identified. Among them, nephrin, podocin, CD2AP, FAT and NEPH1 are accepted to be essential in maintaining the barrier function of the slit diaphragm.
Other data
| Title | Urinary Claudin-1 Level As a Marker of Podocyte Injury in Patients With Proteinuria | Other Titles | قياس نسبة الكلودين -1 في البول كدلالة وجود خلل في خلايا البودوسايت وافراز الزلال بالبول | Authors | Eman Abdel-Mohsen Mousa Sanad | Issue Date | 2018 |
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