Glucose Metabolism in Liver Disease in Children

Abstract

lucose metabolism disorders are frequent in liver cirrhosis. The liver plays a key role in blood glucose control, thus, in the presence of chronic liver disease, the metabolic homeostasis of glucose is impaired and results in glucose intolerance and diabetes mellitus (DM). The liver is a complex multifaceted organ that plays a fundamental role in many processes crucial to bodily function. To accomplish this, the liver is populated with multiple cell types, including hepatocytes, cholangiocytes, stellate cells, endothelial cells, and cells of the immune system (i.e., Kupffer cells). Each cell type performs unique functions essential to the overall performance of the liver.