Retrospective Analysis of Clinical Epidemiology in Gastrointestinal Stromal Tumour
Mustafa Mohamed A. Azim Mohammed;
Abstract
ABSTRACT
Background: GIST is classified into mutation in either KIT or cluster of differentiation 117 (CD117) oncogene (85%), Platelet – drived growth factor receptor alpha gene (PDGFRA) (10%) or rarely B-Raf gene. C.Kit - which is mutated & activated in 80% of GIST- is an oncogene which encodes cell surface receptor Tyrosine Kinase TK (CD117) which is responsible for activation of multiple signaling cascades leading to cellular proliferation.
Background: GIST is classified into mutation in either KIT or cluster of differentiation 117 (CD117) oncogene (85%), Platelet – drived growth factor receptor alpha gene (PDGFRA) (10%) or rarely B-Raf gene. C.Kit - which is mutated & activated in 80% of GIST- is an oncogene which encodes cell surface receptor Tyrosine Kinase TK (CD117) which is responsible for activation of multiple signaling cascades leading to cellular proliferation.
Other data
| Title | Retrospective Analysis of Clinical Epidemiology in Gastrointestinal Stromal Tumour | Other Titles | دراسة ارتجاعية: إكلينيكية وبيئية عن ورم الأنسجة اللحمية للجهاز الهضمي | Authors | Mustafa Mohamed A. Azim Mohammed | Issue Date | 2018 |
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