Hypertriglyceridemia With Total Parenteral Nutrition Versus Enteral Nutrition In Patients With Acute Pancreatitis

Abstract

P is an inflammatory condition of the pancreas that can cause local injury, systemic inflammatory response syndrome, and organ failure. Worldwide, AP is a common gastrointestinal condition and there is evidence that the incidence has been rising in recent years. AP is associated with substantial suffering, morbidity, and cost to the health care system. Inappropriate release and activation of pancreatic enzymes induce acute pancreatitis. The key enzyme in the activation of pancreatic zymogens has been thought to be trypsin. The inappropriate activation of trypsinogen to trypsin and the lack of prompt pancreatic clearance of active trypsin result in pancreatic inflammation and subsequent triggering of the inflammatory cascade. Cytokines including interleukin (IL)-1, IL-6, IL-8, tumor necrosis factor a, and platelet-activating factor are released. These in turn induce the hepatic synthesis of acute phase reaction proteins such as C-reactive protein (CRP). Leukocyte migration and activation may represent the major determining factor for both local and systemic complications.