The relevance of Organic Cation Transporter1 (OCT1) on the response to treatment in adult patients with chronic-phase chronic myeloid leukemia
Heba Mohamed Saber;
Abstract
SUMMARY
C
hronic myeloid leukaemia (CML) is a myeloproliferative
disorder characterized by a reciprocal translocation
between chromosomes 9 and 22 [t (9;22) (q34; q11)], creating
the Philadelphia chromosome and bringing together the
Breakpoint Cluster Region (BCR) and Abelson (ABL1) genes.
The protein encoded by this fusion gene is a dysregulated
tyrosine kinase that phosphorylates multiple downstream
proteins resulting in changes in cell proliferation, DNA repair,
differentiation and cell cycling.
C
hronic myeloid leukaemia (CML) is a myeloproliferative
disorder characterized by a reciprocal translocation
between chromosomes 9 and 22 [t (9;22) (q34; q11)], creating
the Philadelphia chromosome and bringing together the
Breakpoint Cluster Region (BCR) and Abelson (ABL1) genes.
The protein encoded by this fusion gene is a dysregulated
tyrosine kinase that phosphorylates multiple downstream
proteins resulting in changes in cell proliferation, DNA repair,
differentiation and cell cycling.
Other data
| Title | The relevance of Organic Cation Transporter1 (OCT1) on the response to treatment in adult patients with chronic-phase chronic myeloid leukemia | Other Titles | أهمية الناقل العضوى المتأين الموجب 1 فى استجابة مرضى سرطان الدم النخاعى المزمن البالغين المرحلة المزمنة للعلاج | Authors | Heba Mohamed Saber | Issue Date | 2018 |
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