Cognitive Improvement by Duloxetine Administration in demented adult APP/PS1 transgenic AD mouse model
ShamsElDine, Sahar;
Abstract
Alzheimer’s disease (AD) are often associated with memory and cognitive deficits. Effective treatment of these diseases leads to a marked improvement in the cognitive function of such patients. There is a suggestion that there is some neuroprotective properties of duloxetine, as one of the antidepressants, against dementia-associated with cognitive disorders. The present study assessed cognitively enhancing property of duloxetine in a demented adult APP/PS1 transgenic mouse model of AD. Intraperitoneal (ip) administration of a single dose of duloxetine 10 mg/kg/day before each test. This drug treatment rescued cognitive deficits in APP/PS1 mice in both cognitive tests used in this study. The results of the present study suggest that duloxetine administration can help in improvement of cognitive disorder and may inhibit any memory impairement that accompanied the pathogenesis of AD.
Other data
Title | Cognitive Improvement by Duloxetine Administration in demented adult APP/PS1 transgenic AD mouse model | Authors | ShamsElDine, Sahar | Keywords | Duloxetine, Cognition, Dementia, transgenic mice. | Issue Date | May-2015 | Journal | International Journal of Pharmaceutical Science Invention |
Attached Files
File | Description | Size | Format | |
---|---|---|---|---|
duloxetine paper PDF.pdf | 260.26 kB | Adobe PDF | View/Open | |
duloxetine paper PDF.pdf | 260.26 kB | Unknown | View/Open |
Similar Items from Core Recommender Database
Items in Ain Shams Scholar are protected by copyright, with all rights reserved, unless otherwise indicated.