Estimation of Malondialdehyde, Total Antioxidant Capacity, and Selenium Levels in Serum of Intractable Epileptic Children Receiving Treatment with Ketogenic Diet

Abstract

T he most accepted definition for drug resistant epilepsy is failure of adequate trials of 2 tolerated and appropriately chosen and used anti-epileptic drugs (AED) schedules whether as monotherapies or in combination) to achieve sustained seizure freedom. Ketogenic diet is a high-fat, low-carbohydrate, and adequate-protein diet well-established as treatment option for drug resistant childhood epilepsies. Our aim of the current study is to evaluate serum Selenium levels in children receiving KD treatment for intractable seizures for 6 months duration and to verify the efficacy of KD on oxidative stress by evaluation serum MDA and TAC levels.