Effect of Antioxidants on behavioural, biochemical and histopathological modifications (neuroinflammation, neurodegeneration) in Alzheimer's Disease Rat Model
Eman Hany Hassan Abdelnaby;
Abstract
This study was carried out during the period from December 2017 to April 2018 at the Laboratory Animals Unit of Animal Behaviour and Management, Department of Veterinary Hygiene and Management at Faculty of Veterinary Medicine, Cairo University.
The objective of the conducted study was to:
1- Construct and validate an aluminum chloride-induced Alzheimer's disease (AD) model in rats.
2- Evaluate the mitigative effects of different medicinal plants (caffeine, chia extract, and Lepidium Sativum extract) on mood-like behaviour and learning abilities in AD rat model (through monitoring the behavioural, biochemical and histopathological alterations).
3- Assess the protective effects of different medicinal plants (caffeine, chia extract, and Lepidium Sativum extract) on mood-like behaviour and learning ability in albino male rats (through monitoring the behavioural, biochemical and histopathological alterations).
The objective of the conducted study was to:
1- Construct and validate an aluminum chloride-induced Alzheimer's disease (AD) model in rats.
2- Evaluate the mitigative effects of different medicinal plants (caffeine, chia extract, and Lepidium Sativum extract) on mood-like behaviour and learning abilities in AD rat model (through monitoring the behavioural, biochemical and histopathological alterations).
3- Assess the protective effects of different medicinal plants (caffeine, chia extract, and Lepidium Sativum extract) on mood-like behaviour and learning ability in albino male rats (through monitoring the behavioural, biochemical and histopathological alterations).
Other data
| Title | Effect of Antioxidants on behavioural, biochemical and histopathological modifications (neuroinflammation, neurodegeneration) in Alzheimer's Disease Rat Model | Other Titles | تأثير مضادات الأكسدة على التغيرات السلوكية و البيوكيميائية و الهيستوباثولوجية (الالتهاب والتدمير العصبى) في نموذج الجرذان لمرض الزهايمر | Authors | Eman Hany Hassan Abdelnaby | Issue Date | 2018 |
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