Synthesis and Characterization of Some New Azoles and Azines Functionalized with Active Centers for Biological Applications

Abstract

The purpose of this original work is to prepare novel biologically active compounds through the following three parts: Part I: Synthesis of new pyrazoles and pyridines with trimethoxyphenyl scaffold as Combretastatin analogues was archived via reaction of (E)-3-(dimethylamino)-1- (3,4,5-trimethoxyphenyl)prop-2-en-1-one with active nitriles, β-ketoester, 1,3-diketones, heterocyclic amines and hydrazonyl halides. Molecular docking and anticancer screening of the newly compounds were described against HePG-2, HCT-116, MCF-7 and PC3 cancer cell lines. Part II: A new series of compounds containing thiazole nucleus with dimethoxyphenyl scaffold as Rhodanine analogues have been synthesized from the reactions of the thiosemicarbazones with a series of α-halocarbonyl compounds. The new synthesized compounds