SYNTHESIS OF SOME NEW COUMARIN DERIVATIVES AND STUDY THEIR ANTITUMOR ACTIVITY
Ahmed Sabt Ibrahim Mohamed;
Abstract
Coumarin was subjected to chlorosulfonation via chlorosulfonic aicd
to yield coumarin-6-sulfonylchloride
1 which was
utilized as
a key
intermediate
to prepare
new series
from coumarin-6-sulfonamides
derivatives.
Therefore,
compound 1
was refluxed
in ethanol
with
sulfanilamide, pyridine sulfanilamide and/or 4-aminoacetophenone to afford the corresponding coumarin-6-sulfonamides 2 - 4, repectively. N-
(4-acetylphenyl)-2-oxo-2H-chromene-6-sulfonamide 4 reacted with
phenyhydrazine derivatives in absolute ethanol and triethylamineto afford 5a-c. On the other hand, when compound 4 reacted with p-toluene sulfonylhydrazide, compound 6 was isolated. When compound 4 was refluxed with thiosemicarbazide in the presence of ethanol and acetic aicd, the thiosemacarbaone 7 was obtained
to yield coumarin-6-sulfonylchloride
1 which was
utilized as
a key
intermediate
to prepare
new series
from coumarin-6-sulfonamides
derivatives.
Therefore,
compound 1
was refluxed
in ethanol
with
sulfanilamide, pyridine sulfanilamide and/or 4-aminoacetophenone to afford the corresponding coumarin-6-sulfonamides 2 - 4, repectively. N-
(4-acetylphenyl)-2-oxo-2H-chromene-6-sulfonamide 4 reacted with
phenyhydrazine derivatives in absolute ethanol and triethylamineto afford 5a-c. On the other hand, when compound 4 reacted with p-toluene sulfonylhydrazide, compound 6 was isolated. When compound 4 was refluxed with thiosemicarbazide in the presence of ethanol and acetic aicd, the thiosemacarbaone 7 was obtained
Other data
| Title | SYNTHESIS OF SOME NEW COUMARIN DERIVATIVES AND STUDY THEIR ANTITUMOR ACTIVITY | Other Titles | تشييد بعض المشتقات الكومارينية الجديدة ودراسة نشاطها كمضادات للأورام | Authors | Ahmed Sabt Ibrahim Mohamed | Issue Date | 2018 |
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