Molecular and Biological characterization of homemade recombinant human interferon alpha 2b
Rasha Shaaban Zayed;
Abstract
Hepatitis C viral infection in Egypt has one of the highest
prevalence rates in the world. The rhIFN-α2b protein was
approved by FDA as antiviral for HBV and HCV treatment and
anti-tumor drug. Due to their complex nature and the nature of
production process, recombinant pharmaceutical proteins often
contain micro heterogeneity represented in presence of different
forms (isoforms) of the produced protein. We have previously
developed limited pilot scale method for enriched production of
properly refolded rhIFN-α2b isoform in E. coli as intracellular
insoluble aggregate
prevalence rates in the world. The rhIFN-α2b protein was
approved by FDA as antiviral for HBV and HCV treatment and
anti-tumor drug. Due to their complex nature and the nature of
production process, recombinant pharmaceutical proteins often
contain micro heterogeneity represented in presence of different
forms (isoforms) of the produced protein. We have previously
developed limited pilot scale method for enriched production of
properly refolded rhIFN-α2b isoform in E. coli as intracellular
insoluble aggregate
Other data
| Title | Molecular and Biological characterization of homemade recombinant human interferon alpha 2b | Other Titles | "تعيين الخصائص الجزيئية والبيولوجية لانترفيرون الفا 2ب البشري المدمج المصنع محليا" | Authors | Rasha Shaaban Zayed | Issue Date | 2018 |
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