A PharmaceuticaL Study on MethocarbamoL

Abstract

Methocarbamol- is a centrally acting muscle relaxant related structurally to guaifenesin. It is an aromatic glycerol ether and is a close chemical relative to mephenesin carbamate, The mechanism of action due to general nervous system depression. Methocarbamol is indicated to the management of pain and spasm associated with acute painful musculoskeletal disorders. It is also indicated for relieve cases of tension myalgia, acute traumatic muscle spasm, acute disc prolapse, painful shoulderpostoperative joint pain and mechanical low back pam. The chemical name of methocarbamol 1s 3-(o-methoxyphenoxy)-1, 2-propanediol, 1-carbamate. The empirical formula is CIIH15N05 and its molecular weight is 241.24.

The successful formulation of stable and effective dosage form depends on the careful selection of the excipients which are added to facilitate administration, promote the consistent release and bioavailability of the drug and protect from degradation.

'. The most important preformulation information is the drug-excipient

stability study. This object can be acpieved by investigating the stability of the drug in solid-state alone and in presence of different types of excipients chosen according to the type of solid dosage form required.

Some factors may have critical influence on the stability of the drug substances in the presence of the excipients, e.g. drug-to-excipient ratio, moisture and temperature, this requires screening of a rather large number of excipients under several storage conditions of temperature and humidity.

The work in this thesis is divided into four chapters:

Chapter 1: Compatibility of Methocarbamol With Commonly Used

Excipients in Tablets and Capsules.

Chapter II: Formulation and Evaluation ofMethocarbamol Capsules.