On Solving the Gene Silencing Problem via Algorithmic Techniques
Soha Ibrahim Soliman Ibrahim;
Abstract
Some genetic disorder diseases are caused by mutant genes that synthesize harmful proteins causing the initiation and progression of such disorders.
One of the ways to avoid these diseases is to turn off the mutant genes to prevent them from producing the harmful proteins which is known as the Gene Silencing.
The Exogenous gene silencing means designing short interfering RNA sequences in laboratories called siRNA then injecting them into the cell to target a particular messenger RNA(mRNA) of the mutant gene and cause its degradation. The big challenge in this approach is that matching between the designed siRNA and target mRNA do not need to be a perfect matching.
One of the ways to avoid these diseases is to turn off the mutant genes to prevent them from producing the harmful proteins which is known as the Gene Silencing.
The Exogenous gene silencing means designing short interfering RNA sequences in laboratories called siRNA then injecting them into the cell to target a particular messenger RNA(mRNA) of the mutant gene and cause its degradation. The big challenge in this approach is that matching between the designed siRNA and target mRNA do not need to be a perfect matching.
Other data
| Title | On Solving the Gene Silencing Problem via Algorithmic Techniques | Other Titles | عن حل مشكلة إسكات الجينات بإستخدام التقنيات الخوارزمية | Authors | Soha Ibrahim Soliman Ibrahim | Issue Date | 2018 |
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