Control of Biodegradation of Chitosan/Gelatin Scaffolds for Tissue Engineering

Abstract

Large bony defects are serious complications that are most commonly caused by extensive trauma, tumor, infection, or congenital musculoskeletal disorders. If nonunion occurs, implantation for repairing bone defects with biomaterials developed as a defect filler, which can promote bone regeneration, is essential and challenging and the choice between using different degradable devices for maxillofacial applications must be carefully weighed to fulfill the need in specific applications as alveolar ridge augmentation, defect filling after tumor or cyst removal, ridge fixation or as carriers of cells for bone renewal.