Insulin-Like Growth Factor-I and Insulin-Like Growth Factor Binding Protein-I in Obesity and Non-Insulin Dependent Diabetes Mellitus

Abstract

Android obesity and NIDDM are associated with disturbed metabolic and endocrinal patterns in the subjects affected.

Android obesity is usually associated with IGT and high lipid profile. It is also associated with disturbed level of many proteins and hormones, like GH, sex hormones and others.

NIDDM associated with disturbance m carbohydrates, lipids and proteins metabolism, this disturbance depends on the degree of the diabetic control. NIDDM is also associated with disturbance in many hormonal profiles.

The present work aimed to study the effect of both android obesity and NIDDM (each of them in separate and in association with each other) on IGF-1 and IGFBP-1.

To achieve this purpose we measured both IGF-1 and IGFBP-1 in a group of 15 diabetic (non-obese) patients, and another group of 15 obese (non-diabetic) subjects.

To elucidate the synergistic effect of both obesity and NIDDM together, we measured IGF-1 and IGFBP-1 in a third group of 15 obese subjects suffering from NIDDM.

We compared results of the previously mentioned three groups with a fourth group of 15 lean non-diabetic subjects.

It was found that obesity did not affect IGF-1 level, either in diabetics or non-diabetics. While it increased IGFBP-1 level in both diabetics and non-diabetics.