Effect of Quercetin Administration on Lipid Profile, Inflammatory and Oxidative Stress Markers in a Rat Model of Propylthiouracil-Induced Hypothyroidism

Abstract

his study was designed to investigate the possible beneficial effects of quercetin administration on lipid profile, inflammatory and oxidative stress markers in a rat model of propylthiouracil (PTU)-induced hypothyroidism. This study was performed on 45 adult female albino rats allocated randomly into three groups (each group consisted of 15 rats): Control Group: rats received intraperitoneal injection of normal saline, in an equivalent dose to that given with PTU, and received distilled water by gavage equivalent to that given with quercetin. PTU-induced hypothyroid group: rats were intraperitoneally injected with PTU in a dose of 10 mg/kg, b.w./day, 6 days/week for 30 days, then 15 mg/Kg/day, 6 days /week, for another 30 days and continued till the end of the experimental period.