Expression of G Protein–Coupled Receptor 56 (GPR56) in Acute Myeloid Leukemia

Abstract

cute myeloid leukemia is a heterogeneous marrow-based clonal group of neoplasm that affects hematopoietic cells responsible for the production of myeloid lineages. Its diagnosis and sub-classification by FAB and WHO criteria require combination of morphology, cytochemistry, cytogenetics and immune-phenotyping with biological and clinical features to define specific disease entities. The GPR56 belongs to the family G-protein coupled receptors which is one of the largest families of membrane proteins in the human genome, with a variety of physiological functions, thus the richest source of targets for the pharmaceutical industry. Importantly, GPR56 expression is a part of the core signature of functionally validated leukemic stem cells, this 42 gene LSCs signature is prognostic and correlated to patients’ clinical outcome.