Cardioprotective effect of Date Palm Fruit Extract (Phoenix Dactylifera L.) against Doxorubicin-induced cardiotoxicity in rats

Abstract

Doxorubicin (Dox) is a potent antineoplastic agent extensively used in the treatment of several malignancies. Nevertheless, its clinical application carries the risk of serious non-target tissues toxicities, in particular cardiomyopathy, which manifests as life-threatening congestive heart failure. Consequently, there is a much great interest to search for natural compounds with cardioprotective properties to decrease this cardiotoxic effect. The main objective of this study was: 1- To evaluate the antihyperlipidemic and anti-atherogenic effect of date palm fruit extract against alterations in lipid metabolism induced by Dox. 2- To assess antioxidative activity of date palm fruit extract on Dox associated with oxidative stress. 3- To elucidate role of date palm fruit extract in the prevention of alteration in biomarkers of myocardial damage (creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH) and troponin-I) induced by Dox. 4- To monitor the ability of date palm fruit extract to ameliorate the changes in ECG patterns of Dox intoxicated rats.5- To examine the putative preventive effect achieved by date palm fruit extract on histopathological abnormalities induced by Dox.