Protective effects of molokhia leaves against lead toxicity in rat

Abstract

ABSTRACT

Lead (Pb) is considered to be a multi-target toxicant and is a toxic metal that is widespread in the environment from natural and anthropogenic sources, the present study has been undertaken to determine the effect of C.olitorius leaves on lead toxicity in (Pb-acetate) in rats at concentrations (5%,10%,15% and 20%). first main group (7 rats) were fed on standard diet (SD) (negative control). Second main group (35rats) fed on basal diets plus 5% Lead powder to infect rats lead toxicity and then divided to 5 subgroup (n= 7), for each subgroup (1): fed on (SD) + 5% Pb-acetate (positive control). (2): fed on (SD) + 5% Pb-acetate + 5% powdered leaves of C.olitorius. (3): fed on (SD) + 5% Pb-acetate + 10% powdered leaves of C.olitorius. (4): fed on (SD) + 5% Pb-acetate + 15% powdered leaves of Corchorus olitorius. (5): fed on (SD) + 5% Pb-acetate + 20% powdered leaves of C.olitorius. The results were statistically analyzed, the results showed asignificant reduction in serum blood, liver functions. Moreover, decreased uric acid, urea nitrogen and creatinine as compared to control. The results showed that the better result to concentrate (20%), (15%), (10%) then (5%) respectively from leaves of C.olitorius. The leaves of C.olitorius are rich in antioxidants, and they might be responsible for the treatment of lead-induced toxicities.