A Study of Dopamine D2 Receptor Taq1 A Alleles in Children with Attention-Deficit Hyperactivity Disorder

Abstract

Conner scale results distribution of our enrolled ADHD children 78% of them had significant inattention, 66% showed significant hyperactivity; and a significant total ADHD index 74%. Meanwhile, 74% of our studied sample has been proven to have severe type of ADHD on ADHD scale assessment. In the current study; analysis of dopamine D2 TAq1A polymorphism revealed significantly more prevalent A1 allele phenotype among studied ADHD while A2 allele was significantly more prevalent in controls (X2= 4.337, p=0.037). On the other hand; Genotypes A2A2, A1A2, were significantly more prevalent among encountered in ADHD cases compared to controls (p=0.027, 0.047 respectively). Lastly A1A1genotype showed statistically in significant difference comparing cases and controls.