THE POSSIBLE EFFECTS OF INHALATION OF NEBULIZED RECOMBINANT INTERFERON IN BRONCHIAL ASTHMATIC PATIENTS
Hesham Sanad Mohamed Sanad;
Abstract
Recent studies suggest that inhaled cytokine such as recombinant
interferon-gamma (rlFN-y) may play certain role in the treatment of some respiratory conditions associated with inflammation. The present study was designed to determine whether nebulized ri.FN-a at di.!Terent doses could be safely and etTectively delivered in a group of bronchial asthmatic patients. The study was also aiming to shed additional lights on the possible immunological conseqllences of inhaling aerosolized riFN-a on these patients.
This study was enrolled on 30 patients suffering from mild < topic bronchial asthma. They were selected from those attending the Allergy and Immunology Clinic of Ain-Shams University Hospitals. Patients were selected according to positive history of asthma. positive skin prick tests to house dust-mite and/or milk, presence of specific lgE antibodies in sera and other clinical findings.
Total lgE, specific lgE and IL-4 levels were mesured using ELISA method. Turbiquant assay was used to measure other immunoglobulins (G), (A) and (M). Clinical symptom scores, skin test reactivity and histamine sensitivity were remarkably readuced in the patients inhaled nebulized riFN a with. regard to baseline levels. Of interest, the PEFR increased
significantly (p < 0.001), fi•om66.6±4.83%atbaselineto75.3±6.63% alter inhaled riFN-a, indicating the improvement of pulmonary function .. Furthermore. there was a significant reduction in total lgE, specific lgE and IL-4 levels atler treatment, indicating the IFN-u strongly blocked IL-4 • induced lgE synthesis in these patients.
interferon-gamma (rlFN-y) may play certain role in the treatment of some respiratory conditions associated with inflammation. The present study was designed to determine whether nebulized ri.FN-a at di.!Terent doses could be safely and etTectively delivered in a group of bronchial asthmatic patients. The study was also aiming to shed additional lights on the possible immunological conseqllences of inhaling aerosolized riFN-a on these patients.
This study was enrolled on 30 patients suffering from mild < topic bronchial asthma. They were selected from those attending the Allergy and Immunology Clinic of Ain-Shams University Hospitals. Patients were selected according to positive history of asthma. positive skin prick tests to house dust-mite and/or milk, presence of specific lgE antibodies in sera and other clinical findings.
Total lgE, specific lgE and IL-4 levels were mesured using ELISA method. Turbiquant assay was used to measure other immunoglobulins (G), (A) and (M). Clinical symptom scores, skin test reactivity and histamine sensitivity were remarkably readuced in the patients inhaled nebulized riFN a with. regard to baseline levels. Of interest, the PEFR increased
significantly (p < 0.001), fi•om66.6±4.83%atbaselineto75.3±6.63% alter inhaled riFN-a, indicating the improvement of pulmonary function .. Furthermore. there was a significant reduction in total lgE, specific lgE and IL-4 levels atler treatment, indicating the IFN-u strongly blocked IL-4 • induced lgE synthesis in these patients.
Other data
| Title | THE POSSIBLE EFFECTS OF INHALATION OF NEBULIZED RECOMBINANT INTERFERON IN BRONCHIAL ASTHMATIC PATIENTS | Other Titles | التاثيرات المحتمله لاستنشاق رذاذ الانترفيرون المهجن فى مرضى الربو الشعبى | Authors | Hesham Sanad Mohamed Sanad | Issue Date | 2000 |
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