Effects of Coenzyme Q 10 and Vitamin E supplementation on Pentylenetetrazole-induced seizures and Phenytoin-induced cognitive impairment in rats
Marwa Mohamed Nagib Fahmy;
Abstract
Seizures is a hyperexcitability process that involves different parts of the
brain. The etiology and pathogenesis of seizures remains elusive and seems to
be multifactorial, possibly an imbalance in local pro-and anti-inflammatory
cytokines. Neutrophil and monocyte influx occurs with subsequent secretion of
oxygen radicals and enzymes, leading to tissue damage. Many reports using
experimental animal models of acute seizures demonstrated that inflammatory
and oxidative cellular damage are hallmarks of seizure and probably play a key
role in its production.
brain. The etiology and pathogenesis of seizures remains elusive and seems to
be multifactorial, possibly an imbalance in local pro-and anti-inflammatory
cytokines. Neutrophil and monocyte influx occurs with subsequent secretion of
oxygen radicals and enzymes, leading to tissue damage. Many reports using
experimental animal models of acute seizures demonstrated that inflammatory
and oxidative cellular damage are hallmarks of seizure and probably play a key
role in its production.
Other data
| Title | Effects of Coenzyme Q 10 and Vitamin E supplementation on Pentylenetetrazole-induced seizures and Phenytoin-induced cognitive impairment in rats | Other Titles | تأثيرات المكملات مساعد الإنزيم كيو ١٠ و فيتامين (هـ) على التشنجات التي يسببها البنتيلين تترازول و التدهور الإدراكي الناجم عن الفينيتوين في الجرذان | Authors | Marwa Mohamed Nagib Fahmy | Issue Date | 2018 |
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