The Study of The Immune System In Sepsis

Abstract

Sepsis is the systemic inflammatory response syndrome to infection. Mortality rate ranging from 20 % to 80%. It is now generally accepted that sepsis results from an extensive, unchecked triggering of the body•s immune system which stimulate the release of number of cytokines which activate macrophages, neutrophils and activate plasma protein cascade systems such as complement, coagulation, contact systems and the fibrinolytic system which all leads to endothelial damage and release of subendothelial tissues•s proteolytic enzymes. Such an overwhelming immune response cause diffuse capillary injury, tissue damage, and tissues hypoxia resulting in organ dysfunction and death. More understanding of the role of immune system and new therapies modulating this role carry a new hope for improving sepsis prognosis.