Prediction of mortality in Chronic obstructive pulmonary disease patient

Abstract

Chronic obstructive pulmonary disease is considered multifactorial disease caused by many factors including smoking, air pollution, occupational exposure, genetics and other causes . Pathophysiology of COPD includes mucus hyper secretion, ciliary dysfunction, air flow limitation, hyperinflation, gas exchange abnormalities and pulmonary hypertension, core pulmonale. Recently oxidative stress, protease and anti-protease imbalance is involved in pathophysiology of COPD. There are many clinical predictors of mortality are newly involved in prediction of mortality of COPD including FEV1 which is most tested and accepted clinical predictor. Other clinical predictors include BODE index, spirometry, Dyspnea score, DOSE score and DECAF score.