Biochemical Study on the Effect of a Novel Gallium Complex and Its Derivatives on Metallo-Collagenase Activity In Vitro
Ahmed Mohsen Mohamed Moussa;
Abstract
Abstract
It was shown in the 1980s that gallium salts may have anti-tumor
activity in animals. Unfortunately, clinical trials with either nitrate or
gallium chloride have failed for a variety of reasons including low
bioavailability, renal toxicity, and rapid onset of gallium resistance. So, the
main task of our work was to prepare and characterize the chemical structure
of some new water-soluble bioavailable gallium complexes derived from
aspartic acid and to study their possible biochemical effects on the activity
of metalloproteinases (collagenases) as a possible promising mechanism to
control the invasion of some metastatic tumors.
It was shown in the 1980s that gallium salts may have anti-tumor
activity in animals. Unfortunately, clinical trials with either nitrate or
gallium chloride have failed for a variety of reasons including low
bioavailability, renal toxicity, and rapid onset of gallium resistance. So, the
main task of our work was to prepare and characterize the chemical structure
of some new water-soluble bioavailable gallium complexes derived from
aspartic acid and to study their possible biochemical effects on the activity
of metalloproteinases (collagenases) as a possible promising mechanism to
control the invasion of some metastatic tumors.
Other data
| Title | Biochemical Study on the Effect of a Novel Gallium Complex and Its Derivatives on Metallo-Collagenase Activity In Vitro | Other Titles | دراسة كيميائية حيوية على تأثير مركب جاليوم جديد و مشتقاته على نشاط إنزيم الميتالوكولاجينيز خارج الجسم | Authors | Ahmed Mohsen Mohamed Moussa | Issue Date | 2019 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| j9493..pdf | 182.42 kB | Adobe PDF | View/Open |
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