(The Influence of Citric Acid Bone Surface Etching and Bone Substitute Intra-Osseous Defect Fill on Crevicular Fluid BMP-2 Release Profile (Randomized Clinical Trial

Abstract

Chronic periodontitis is regarded as an inflammatory disease that affects the supporting tissues of teeth which could lead to bone destruction. According to the pattern of bone destruction, vertical infrabony defect could occur. Several biomaterials have been used to treat infrabony defects including bone grafts, membranes, growth factor & Enamel matrix proteins. Bone derived xenograft is a type of bone graft which has been widely used in the treatment of infra-bony defects. Chemical treatment of root surfaces of teeth have been used as an adjunct with mechanical instrumentation. Among these chemical agents is citric acid which was found to be able to remove the smear layer and expose the collagen fibers on the root surface which would make the root surface biocompatible favoring fibroblast attachment. However, studies have found that there was no clinical significance of citric acid when it was used as a root conditioner