The biological behaviour of bioactive glass and calcium phosphate bone graft materials in vivo

Abstract

Result of this study suggested that silica-calcium phosphate composite (SCPC ) has the ability to stimulate rapid bone generation and resorb when grafted in large bone defect . The excellent bioactivity of SCPC is due to their unique chemical composition, crystalline structure and porosity . The bone conductive effect and resorbability of SCPC were superior to those of Bioglass® . X-ray diffraction analysis of these silica-based calcium phosphat2 composite showed that they are characterized by a unique bioactive resorbable crystalline phases . XRD anal ysis of C3S1 sample showed characteristic peaks of -Ca2P207 , a-cristobalite and -NaCaP04 . On the other hand , C1S1 and C1S3 samples treated at the same temperature composed mainly of

-NaCaP04 and a-cristobalite . In addition , weak signals for low quartz and Na2Si20s ( alpha ill form ) appeared in XRD spectra of CIS I and C1S3 samples respecti vely . These crystalline phases are known to have good biological activity when used individually .The formation of -NaCaP04 is known to enhance the bioactivity of the composites. Data in the literature have showed that -NaCaP04 may posses a higr potency than tricalcium phosphate (TCP) and the other calcium phosphate , thereby promoting osteogenesis and matrix calcification . On the other hand calcium pyrophosphate( -Ca2P207 l has a wide applications in the manufacture of oral care products like paste and also it is sold as a mineral supplement .Also ,calcium pyrophosphate can be used as a coating material for bone and teeth implant .