Effect of Perioperative Alpha1-Blocker on Non-Stented Ureteroscopic Laser Lithotripsy for Ureteric Stones

Abstract

owadays, ureteroscopy is the first line of surgical treatment of ureteric stones and holmium YAG laser is commonly used in stone fragmentation. Guidelines 2018 recommended not fixing ureteric stent in uncomplicated ureteroscopy. Therefore, when we decrease intra-operative dilatation, we may decrease the complicated ureteroscopy. Alpha1 blocker has an action on lower ureter, bladder and prostatic urethra. It is used as MET and in ureteroscopy. Our study was conducted at Urology Department, Ain Shams University Hospitals and National Institute of Urology and Nephrology starting from September 2017 to December 2018. Sixty patients with lower ureteric stone included in this study underwent non-stented laser lithotripsy and were divided into two equal groups; group A (tamsulosin) and group B (no tamsulosin). Our study revealed that using peri-operative tamsulosin statistically reduced the need for ureteric dilatation, mean operative time, mean hospital stay, post-operative pain, the need for pain medications and post-operative lower urinary tract symptoms. Furthermore, the number of patients who developed post-operative fever and hematuria in group A was lower than those in group B. However, these results were statistically insignificant.