THE EFFECT OF MISOPROSTOL ON MENSTRUAL BLOOD LOSS OF DYSFUNCTIONAL MENORRHAGIA

Abstract

Objective: To evaluate the efficacy .of misoprostol m treatment of dysfunctional menorrhagia. Design: Prospective case control randomized study. Setting: Benha University hospital clinic & EL-Amrea central hospital clinic- Alexandria. subject: Forty women diagnosed as having dyfunctional menorrhagia (ascertained by blood hemoglobin, hematocrite, number of menstruation days, estimated blood loss(EBL) and pictorial blood loss assessment chart(PBLAC). Women were divided into two groups each containing 20 women. One pretreatment cycle was compared with two treatment cycles. One group was given oral misoprostol and the other .group was given placebo for two consequent cycles each for two treatment cycles. Misoprostol and placebo treatment two cycles were compared. Comparing the 1st and 2nd cycles of misoprostol with the 1st and 2nd placebo cycles respectively. Results: group I (misoprostol group) : the mean differences(post-trial minus pretrial) in hemoglobin and hematocrite were statistically significant. Also significant reduction )Jet\\{een baseline and treatment cycles was present. The mean differences of number of menstruation days between the baseline and 1st and 2nd treatment cycles were significant. The mean differences of EBL between the baseline and 1st and 2nd treatment cycles were significant. Also the mean difference of EBL between the 1st and 2nd treatment cycles was significant. The mean difference of PBLAC between the baseline and 1st and 2"d treatment cycles were significant.