STUDIES OF LIVER FUNCTION TESTS IN CASES OF LIVER TOXICOSIS

Abstract

I I Chemotheripy for blood parasites in animals as Trypanosoma and

Babesia . species hIas a great importance invete. rinary medicine. One. of these drugs is d minazine aceturate "BerenilQsJ" a product of Hoechst

Company "GermJny" which used on large scale as a trypnocidal and babesiacidal drug,\ This wm'k was can,ied out to study the toxic effect of Berenil® on white lbino rats through its effect on some blood parameters in additioi1 to bhanges in liver and kidney functions beside histopathological cJanges due to repeated administration of the dmg, 1

. In this study e used 200 albino rats each weighing 150-200 gm, w

all ofthese a.nimals wIere in good hygienic condition. Our study inclbdes three parts: . , I (1) . The first part: 1 This part dealslwith the determination oflethal dose 50 (LD50 ) and 1

toxic symptoms of Be enil® on rats, about 50 albino rats were used in this I I work. From our study it can be concluded that the LD50 of Berenil® in rats

was 170 mg/Kg. B.wt intramuscularly, and signs of toxicity includes

depress1•0n, m•

coordenIat1•0n, l

.tremors,

frequent urm• at.Ion and the

respiration was shalloW, rapid, irregular followed by death. I , I I l