Comparative Efficacy and Safety of a Fixed- Dose Combination Therapy of Tamsulosin and Tadalafil versus Tadalafil alone for BPH Patients with Lower Urinary Tract Symptoms and Erectile Dysfunction

Abstract

Considering the high incidence of ED and BPH in aging men and the same pathophysiology and the probability to treat both disorders with the same treatment (alpha blockers and/or phosphodiesterase type 5 [PDE5] inhibitors. In our analysis the aim of our study to assess the efficacy and safety of fixed-dose combinations therapy of Tamsulosin 0.4 mg plus Tadalafil 5mg versus Tadalafil 5mg alone once daily in treatment for BPH patient with lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). In this prospective randomized clinical study Fifty patients >45 years old complaining of LUTS due to BPH and erectile dysfunction were randomaly divided into two groups.