Potential therapeutic effect of allogenic mesenchymal stem cells in chronic cerebral murine toxoplasmosis
Nermeen Mohammed Abd El-Samee;
Abstract
Abstract
Toxoplasmosis is an infectious disease caused by an obligate intracellular parasitic protozoan, Toxoplasma gondii (T. gondii). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are self-renewing, clonal precursors of non-haematopoietic tissues, with anti-inflammatory and anti-apoptotic effect. They can repair and restore several tissues, including the CNS.
This study aimed to evaluate the therapeutic effect of BM-MSCs on murine chronic toxoplasmosis experimental model. BM-MSCs were obtained from tibiae and femurs of 7-wk-old Albino donor rats. Nucleated cells were cultured and incubated till become confluent.
Toxoplasmosis is an infectious disease caused by an obligate intracellular parasitic protozoan, Toxoplasma gondii (T. gondii). Bone marrow-derived mesenchymal stem cells (BM-MSCs) are self-renewing, clonal precursors of non-haematopoietic tissues, with anti-inflammatory and anti-apoptotic effect. They can repair and restore several tissues, including the CNS.
This study aimed to evaluate the therapeutic effect of BM-MSCs on murine chronic toxoplasmosis experimental model. BM-MSCs were obtained from tibiae and femurs of 7-wk-old Albino donor rats. Nucleated cells were cultured and incubated till become confluent.
Other data
| Title | Potential therapeutic effect of allogenic mesenchymal stem cells in chronic cerebral murine toxoplasmosis | Other Titles | التأثير العلاجي المحتمل للخلايا الجذعية الوسيطة الألوجينية على داء المقوسات الدماغي المزمن | Authors | Nermeen Mohammed Abd El-Samee | Issue Date | 2019 |
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