Combination Vs Single antibiotics for prevention of surgical site infection during caesarean section in obese women Randomized controlled trial

Abstract

The rate of obesity among women has been increasing, and obesity is associated with increased risk of surgical site infection (SSI) following cesarean delivery .Obesity is associated with comorbidities, anatomical factors (ie, skin folds and increased tissue pressure), and bioactive adipose tissue that increase the risk of SSI Adipose tissue is highly active and secretes a wide range of hormone factors, chemokines, and, importantly, cytokines, regulating inflammation and oxidative stress .Limited studies have addressed optimal antibiotic regimens for the prevention of SSI among obese women,hence, a cost minimization approach was employed in developing guidelines. When antimicrobials have been shown to be equally efficacious and safe, the recommendation is based on the least high cost agent. The other antimicrobials are considered to be alternative agents .