Effect of Cyclosporine A on Hearing in Children with Steroid Resistant Nephrotic Syndrome
Ahmed Tarek Abdel Fattah Soliman;
Abstract
The aim of this study is to assess hearing defects in children with steroid resistant nephrotic syndrome (SRNS), before and after receiving CsA for 6 months.
Twenty five pediatric patients with SRNS in pediatric nephrology clinic, Children's hospital, Ain Shams University, were trialed to evaluate hearing defects before and after receiving CsA for 6 months.
Patients were subjected to history taking including (age, gender, age at first clinical presentation, reports of biopsies, systemic diseases, ear problems, previous ENT operations and ototoxic drug intake). Basic audiological evaluation including (Pure Tone Audiometry, Speech Audiometry and Acoustic Immitancemetrey) were done before and 6 months after initiation of CsA treatment.
Valid cases showed that the average mean hearing threshold shows non-significant changes before and after six months of cyclosporine treatment with (p= 0.954) at 250 Hz, (p= 0.868) at 500 Hz, (p= 0.473) at 1000 Hz, (p= 0.680) at 2000 Hz, (p= 0.535) at 4000 Hz and (p= 0.865) at 8000 Hz respectively.
There was no correlation between age, weight, height, age at first clinical presentation, duration of corticosteroid intake, regarding average of hearing before and after six months of cyclosporine treatment.
Concerning speech and language evaluation, all patients had bilateral excellent speech discrimination before and after CsA treatment
Twenty five pediatric patients with SRNS in pediatric nephrology clinic, Children's hospital, Ain Shams University, were trialed to evaluate hearing defects before and after receiving CsA for 6 months.
Patients were subjected to history taking including (age, gender, age at first clinical presentation, reports of biopsies, systemic diseases, ear problems, previous ENT operations and ototoxic drug intake). Basic audiological evaluation including (Pure Tone Audiometry, Speech Audiometry and Acoustic Immitancemetrey) were done before and 6 months after initiation of CsA treatment.
Valid cases showed that the average mean hearing threshold shows non-significant changes before and after six months of cyclosporine treatment with (p= 0.954) at 250 Hz, (p= 0.868) at 500 Hz, (p= 0.473) at 1000 Hz, (p= 0.680) at 2000 Hz, (p= 0.535) at 4000 Hz and (p= 0.865) at 8000 Hz respectively.
There was no correlation between age, weight, height, age at first clinical presentation, duration of corticosteroid intake, regarding average of hearing before and after six months of cyclosporine treatment.
Concerning speech and language evaluation, all patients had bilateral excellent speech discrimination before and after CsA treatment
Other data
| Title | Effect of Cyclosporine A on Hearing in Children with Steroid Resistant Nephrotic Syndrome | Other Titles | تأثير السيكلوسبورين أ على السمع لدى الأطفال الذين يعانون من المتلازمة الكلوية المقاومة للكورتيزون. | Authors | Ahmed Tarek Abdel Fattah Soliman | Issue Date | 2019 |
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