Randomized Controlled Clinical Study to Compare the Effect of Intravenous Magnesium Sulphate Versus Diclofenac Sodium As Post Operative Analgesic After Abdominal Hysterectomy Under General Anaesthesia

Abstract

Hysterectomy is the most common major gynaecological operation and second most common surgery done after caesarean section all over the world. Abdominal hysterectomy is associated with postoperative pain. Traditional methods for postoperative pain management include opioids administered systemically using patient-controlled intravenous analgesia (PCA), or neuroaxially via epidural or spinal injections. However, pain relief, specifically on movement, is not always adequately controlled when using PCA, despite moderate to large doses of morphine. This is associated with side-effects such as postoperative nausea and vomiting (PONV), tiredness, pruritus, headache, and constipation. The major goal in postoperative pain management is to minimize the dose of medications and decrease side effects, while still providing adequate analgesia. Postoperative pain relief leads to earlier mobilization, shortened hospital staying, reduced hospital costs, and increased patient satisfaction. The study aim to compare the effect of intravenous magnesuim sulfate versus intravenous diclofenac on postoperative analgesia in patients undergoing total abdominal hysterctomy.