BIG ENDOTHELIN-1 LEVEL AS A PREDICTIVE MARKER FOR THE PRESENCE OF ISOLATED CORONARY ARTERY ECTASIA IN PATIENTS PRESENTED WITH CHEST PAIN

Abstract

In this study we aim to investigate the the relationship between big ET-1 level and isolated CAE in patients presented with chest pain, admitted to Ain-Shams University hospitals. This study was conducted on 55 patients presented to the hospital because of cardiac symptoms (chest pain, dyspnea, unstable and stable angina). They were subjected to coronary angiography because of chest pain, and/or positive treadmill test, and/or positive coronary CT scan and/or presence of multiple coronary risk factors. All patients were subjected to 1) detailed medical history taking with special emphasis on risk factors for developing coronary artery disease e.g. age, diabetes, hypertension, smoking, family history of premature cardiovascular disease. All patients with history of untreated thyroid disease, estrogen replacement therapy, carcinoma, poorly controlled hypertension (systolic blood pressure>160 mmHg or diastolic blood pressure>105 mmHg), recent major operation (<3 months), autoimmune disease were excluded from the study 2)Thorough clinical examination, ECG and Echocardiography to exclude any patient with history or evidence of valvular heart disease, congestive heart failure, left ventricular dysfunction, echocardiographically proven left ventricular hypertrophy, sinus node dysfunction or conduction disturbance.