Accelerated partial breast irradiation using 3D conformal radiation therapy versus whole breast irradiation in patients with early breast cancer.

Abstract

In 2016, it is estimated that among U.S. women there will be 246,660 new cases of invasive breast cancer, 61,000 new cases of in situ breast cancer and 40,450 breast cancer deaths (American Cancer Society 2016) In 2013 the estimated age-adjusted annual incidence of breast cancer in the European Union (25 countries) was 110.6/100, 000 and the mortality 24.0/100 000 (Ferlay et al., 2013). In Egypt, breast cancer is the most common cancer in females, it represents 37.6% of all cancer cases in Gharbia cancer registry and 31.5% of all cancer cases presented to the NCI between the year 2011 and 2014 (Ibrahim etal, 2014). Early stage breast cancer is defined as stage II or less on the basis of the lack of lymph node, metastasis & the clinical lesion size less than 5 cm. Most women who are newly diagnosed with early stage breast cancer have a choice of breast conserving Therapy (BCT). (Suzuki et al, 2006). Breast conserving therapy (BCT) consists of resection of the primary breast tumor (lumpectomy, segmental mastectomy or wide local excision) followed by whole breast irradiation (WBI). (Fisher et al, 2002). The main aim of external beam radiotherapy (EBRT) for early