The potential diagnostic value of immunohistochemical expression of TROP 2 in papillary thyroid carcinoma

Abstract

The incidence and mortality of thyroid carcinomas are rapidly rising worldwide accounting to around 3.4% of newly diagnosed cases of cancer in 2017 (Siegel et al., 2017). The global thyroid cancer burden is estimated, according to the National Cancer Institute statistics in 2017, to have increased to 56,870 new cases and 2010 deaths (Siegel et al., 2016). The most common histopathological type is papillary thyroid carcinoma (PTC) which accounts to around 60% to 80% of all thyroid carcinomas in adults (Halkova et al., 2016; Haugen et al., 2015).