Study of in Vitro Susceptibility of Fosfomycin among Enterobacteriaceae Clinical Isolates Causing Community Acquired Urinary Tract Infection

Abstract

U TIs are the most common type of human bacterial infections. Over 150 million cases of UTIs occur annually in the world. It is caused by a range of pathogens, but most commonly by E. coli, K. pneumoniae and Proteus mirabilis. The prevalence of antibiotic resistance among uropathogenic Enterobacteriaceae is remarkably high. These cases represent a therapeutic challenge to physicians as the availability of treatment options is limited. This rapid increase in antibiotic resistance necessitates searching for alternatives. Since the availability of new antimicrobial agents is limited, so reevaluation of older antibiotics may be of help. Among older antibiotics, Fosfomycin is an attractive choice since it is a broad spectrum antibiotic that is indicated in treatment of UTI. It is a bactericidal antibiotic that interferes with cell wall synthesis in both Gram-negative and Gram-positive bacteria.