Minimal Residual Disease in Acute Myeloid Leukemia patient

Abstract

t was thought that successful treatment of AML is based only on the achievement of morphological CR (mCR), defined as less than 5% leukemic cells, counted by light microscopy, within a fully restored BM cellularity. However, it is now clear that classical morphology examination neglects a minority of myeloid blasts that could survive after induction and consolidation cycles that is known as MRD. MPFC provides a quick and relatively inexpensive method for MRD detection, which is applicable to the vast majority of patients with AML.