Association of CYP2J2 Gene Polymorphism with Ischemic Stroke

Abstract

Stroke is regarded as a severe disorder with high morbidity and high mortality, which is a major healthcare problem and a serious economic burden worldwide. It claims over 6 million deaths each year worldwide (Abd-Allah and Moustafa, 2014). The CYP2J2 gene is a member of cytochrome P450 (CYP) superfamily, spans ∼40.3 kb on human chromosome 1, band p31.3–p31.2 (King et al., 2002). The epoxygenation of arachidonic acid (AA) by CYP2J2 is efficient and generates epoxyeicosatrienoic acids (EETs) (Capdevila et al., 2007). Epoxyeicosatrienoic acids has a series of positive effects, such as dilating blood vessels, anti-inflammatory, antithrombotic, promoting the angiogenesis and the growth of endothelial cells (Polonikov et al., 2007). To date, some studies have identified that the CYP2J2 -50G>T variant may increase the risk of IS, whereas others have not found an association between variation in CYP2J2 and stroke (Liu et al., 2007).