(Relationship between the Interval between Time of Oocyte Retrieval and Time of Human Chorionic Gonadotropin (hCG) Injection and Pregnancy Outcome after in vitro fertilization and embryo transfer (IVF-ET

Abstract

The time from hCG administration to OPU is the period of oocyte maturation in vivo, and it has a predominant effect on the success of IVF, either by in vitro insemination or ICSI. The standard recommended interval from hCG administration to oocyte pickup (OPU) is 34–38 hours. This ensures the completion of follicular development and oocyte maturation in most cases and significantly reduces the risk of spontaneous ovulation (Bokal et al., 2005). The scientific literature varies regarding the ideal time interval between oocyte maturation trigger and aspiration. Some studies have found that longer lag times do not lead to more mature oocytes or better clinical results, whereas other studies have found that longer lag times may produce more mature oocyt or improve other clinical parameters (Griffin et al., 2012).