Study on the liability of limiting the progression of Chronic Kidney Disease by the use of Probiotics, symbiotic and activated charcoal in Experimental Albino Rats

Abstract

This study was designed to investigate the possible role of probiotics, symbiotic and activated charcoal in limiting the influx of bacterial toxins to systemic circulation to limit progression of CKD in experimental albino rats. Experimental groups: Animals were divided randomly into the following groups (group I, II comprised of 10 rats, each of the other groups comprised of 20 rats):  Group I: sham control  Group II:5/6thnephrectomized rats for 6 weeks (Sugano et al., 2008).  Group III: included two subgroups A- 5/6th nephrectomized rats for 6 weeks on probiotics: Treated with 1 × 1010 CFU/kg/day for Lactobacillus acidophilus (Yoshifuji et al., 2015 with little modification) prepared by Dairy and Food Microbiology Department of National Research Center: Treatment started immediately after surgery