Levetiracetam versus phenytoin for seizure prophylaxis in patient with traumatic brain injury

Abstract

Traumatic brain injury (TBI) is a serious neuro-disorder commonly caused by road traffic accidents (RTAs), sports related events or violence. It is one of the leading causes of disability and death of young adults in industrialized countries presents a major worldwide social, economic, and health problem. TBI are classified according to severity, physical mechanism, pathophysiology and CT findings. Secondary brain injuries are defined as the constellation of cellular and biochemical processes that are set in motion by the primary injury and then evolve over the subsequent hours and days. They include cerebral edema, hematomas, hydrocephalus, intracranial hypertension, vasospasm, metabolic derangement, infection, and seizures.