Effect of Silodosin versus Darifenacin versus Combination of Both Drugs for Ureteric Stent Related Symptoms

Abstract

The mechanism of action of selective alpha A1 blocker Silodosin as medical treatment for ureteric stent related symptom is blockage of adrenergic receptors especially α1-adrenergic receptors in the detrusal muscle layer of bladder and intramural part of ureteric smooth muscle cells resulting in selective relaxation of the ureteric smooth muscle and therefore, decreases the pain with side effect as retrograde ejaculation and less CVS side effects as orthostatic hypotension. While the mechanism of action of antimuscarinic selective m3 blocker Darifenacin as medical treatment for ureteric stent related symptom is to reduce the frequency of contractions by antagonizing parasympathetic control of the bladder; they also may alter bladder sensation during filling with side effects as xerostomia, blurred vision, and GI side