STUDY OF LUMBAR SPINE BONE DENSITMETRY IN .DEPOT-MEDROXY PROGESTERONE ACETATE USERS
Atyat Saad Shehata Hassan;
Abstract
ept-Medroxy Progesterone Acetate (DMPA) an injectable progestogen , is a contraceptive method, that is widely used in over 100 countries around the world. It works primarily by inhibiting pituitary gonadotrophin secretion and consequently suppressing ovulation. Ovarian production of
estrogen is also decreased
Estrogen deficiency states are a recognized for being associated with accelerated bone loss and osteoprosis e.g., ovulation dysgenesis (Turner's syndrome) therefore, there is growing concern about the potential development of osteoprosis with the contraceptive use of DMPA, especially when a case was reported in 1994 for a woman with multiple fractures while on DMPA for 17 years.
This study examined one hundred and twenty-five women. Twenty-five who had been using DMPA for contraception for more than 2 yeas (as cases) and one hundred who had never used DMPA or any hormonal contraception (as control). In all women included, serum e a iol levels and bone mineral density of lumbar spine using DEXA were assessed. The results showed that women on DMPA had serum estradiol levels, mean 89.8 pg/ml (which is lower than mid follicular phase range), while in controls were 22.37 pg/ml. With the difference being of statistical significance (p < 0.05).
Bone Mineral Density (BMD) measurement off lumbar spine showed that women on DMPA had low BMD oflumbar spine with mean 1.002 gm/cm2 with the difference being of
estrogen is also decreased
Estrogen deficiency states are a recognized for being associated with accelerated bone loss and osteoprosis e.g., ovulation dysgenesis (Turner's syndrome) therefore, there is growing concern about the potential development of osteoprosis with the contraceptive use of DMPA, especially when a case was reported in 1994 for a woman with multiple fractures while on DMPA for 17 years.
This study examined one hundred and twenty-five women. Twenty-five who had been using DMPA for contraception for more than 2 yeas (as cases) and one hundred who had never used DMPA or any hormonal contraception (as control). In all women included, serum e a iol levels and bone mineral density of lumbar spine using DEXA were assessed. The results showed that women on DMPA had serum estradiol levels, mean 89.8 pg/ml (which is lower than mid follicular phase range), while in controls were 22.37 pg/ml. With the difference being of statistical significance (p < 0.05).
Bone Mineral Density (BMD) measurement off lumbar spine showed that women on DMPA had low BMD oflumbar spine with mean 1.002 gm/cm2 with the difference being of
Other data
| Title | STUDY OF LUMBAR SPINE BONE DENSITMETRY IN .DEPOT-MEDROXY PROGESTERONE ACETATE USERS | Other Titles | دراسة كثافة عظام الفقرات القطنية فى مستخدمات حقن خلات مدروكسى بروجستيرون المختزن | Authors | Atyat Saad Shehata Hassan | Issue Date | 2002 |
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