Role of micro RNA125a and Pulsatile Hemodynamics Parameters in Assessment of Pulmonary Arterial Hypertension in Congenital Heart Disease

Abstract

ulmonary arterial hypertension (PAH) is a condition characterized by increased pulmonary arterial blood pressure and resistance in the arterial vasculature of the lung. It may arise as an idiopathic disorder, or is often associated with secondary disorders. Clinically, the disease is defined as a mean pulmonary artery pressure of >25 mmHg at rest. PAH is a relatively common complication in patients with CHD, affecting both disease progression and prognosis. Elevated RV afterload leading to RV failure is the main determinant of mortality in PAH.