Clinical and Histological Evaluation of The Healing of Meshed Skin Grafts of Different Meshing Sizes Covered by Fresh Amniotic Membrane Dressings

Abstract

With the development of the meshed skin graft and the availability of different meshing expiation sizes, the sizes of the open areas of the meshed skin grafts interstices (gaps) are similar to all open wounds increase the metabolic needs of these patients and put them at the risk of bacterial infection. The amniotic membrane satisfies most of the criteria for an ideal biological wound dressing. It is thin, transparent with excellent adherence properties to the wound and provides an effective barrier, a durable coverage for the wound bed, pain relief with bacteriostatic properties and rapid re-epithelization. The aim of this study was to determine the rate of in vivo healing of the meshed skin autograft with different meshing sizes applied to post burn raw areas when covered by fresh amniotic membranes. Histological and clinical examination will determine the features of the tissues that filled the gaps (interstices) of meshed skin autografts From October 2015 to Mars 2018, in a prospective experimental, multicenter clinical study, 45 patients in both Ain shams and Minia universities burn units with post burn raw areas (healthy granulating raw areas) and clean (non-infected). The patients included in this study, have post burn raw areas with total body surface areas less than 30%. The patients were divided into three main groups.