Assessment of Serum IL-15 in Adult Acute Leukemia Patients

Abstract

his study was conducted to assess expression of IL-15 level in adult Egyptian acute leukemia patients, its correlation with disease free survival, overall survival and relapse rate, as well as its possible correlation with other prognostic parameters. Serum IL-15 was much higher in patients with ALL than the control subjects (P = 0.015). ALL patients with high risk cytogenetics had lower serum IL-15 level compared to those with non-high risk cytogenetics (P = 0.047). No correlation could be found between serum IL-15 level and total leucocytic count, risk stratification in patients with ALL (P = 0.572) and (P = 0.411) respectively. ALL patients with high serum IL-15 level achieved 1st complete response (CR) less than those with low or average serum IL-15 level (P = 0.038). ALL patients with high serum IL-15 level achieved minimal residual disease (MRD) negativity less than those with low or average serum IL-15 level (P = 0.006). No correlation could be found between serum IL-15 level and relapse rate in patients with ALL (P = 0.157).